Cis-regions and trans-factors controllingTCL1 oncogene expression are not known. We
identified the functional TCL1 promoter by mapping four transcriptional start sites 24–30 bp …

SV40 transforms cells through the action of two oncoproteins, large T antigen and small t
antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell …

We now understand neoplastic transformation to be the consequence of multiple acquired
genetic alterations. The combination of these acquired changes confer the various …

Abstract The simian virus 40 (SV40) major late promoter is subject to both positive and
negative regulation. SV40 large tumor antigen (Tag) activates this promoter; however, the …

Hepatocellular carcinoma (HCC) is a highly aggressive cancer with no currently available
effective treatment. Understanding of the molecular mechanism of HCC development and …

Herpes simplex virus (HSV)‐1 stimulation‐related gene 1 (HSRG1) protein expression is
induced in HSV‐1 infected cells. We found that HSRG1 interacts with SV40 large T antigen …

The large tumor antigen of simian virus 40 (SVLT) is a potent oncogene. Although
inactivation of the p53 and pRb tumor suppressors has been causally linked to the …

Transcription factor LSF is required for progression from quiescence through the cell cycle,
regulating thymidylate synthase (Tyms) expression at the G1/S boundary. Given the constant …

Signals induced by granulocyte colony-stimulating factor (G-CSF), the major cytokine
involved in neutrophil development, are tightly controlled by ligand-induced receptor …

SCL is a basic domain helix-loop-helix (bHLH) oncoprotein that is involved in T-cell acute
lymphoblastic leukemia as well as in normal hematopoiesis. Although it is believed that SCL …