Fractionation of HeLa cell extracts reveals the presence of a promoter-specific transcription
factor, Spi, which activates a class of promoters that includes the SV40 early promoter but …

Gfi-1 is a cellular proto-oncogene that was identified as a target of provirus integration in T-
cell lymphoma lines selected for interleukin-2 (IL-2) independence in culture and in primary …

Abstract The simian virus 40 (SV40) enhancer element is constituted of two domains which
contain sequences important for late transcription (M. Ernoult-Lange, F. Omilli, D. O'Reilly …

SV40 large T antigen is a multifunctional regulatory protein that plays a key role in the viral
life cycle and can stimulate cell proliferation. To accomplish this, large T antigen has to …

While it is clear that cancer arises from the accumulation of genetic mutations that endow the
malignant cell with the properties of uncontrolled growth and proliferation, the precise …

The Simian Virus 40 (SV40) small-t antigen (ST) plays an important role in driving cell
proliferation, enhancing transformation by the large-T (LT) antigen. Potential targets of ST …

We describe the cDNA encoding the SV40 transcriptional enhancer factor 1 (TEF-1) and
show that its translation initiates exclusively at an AUU codon in vivo. Cloned TEF-1, which …

Deletion and substitution mutations in the control region of simian virus 40 (SV40) were
used to study regulation of early transcription by T antigen. A mutant, plN4, containing …

A growing body of literature suggests that the ubiquitously expressed Src family kinases
(Src, Fyn and Yes) are required for agents such as platelet-derived growth factor (PDGF) to …

This chapter has outlined our current understanding of the regulation of p70S6K activity and
its importance for cell growth and proliferation. Although incomplete at the moment, the …