Abstract Mutant RAS (RAS V12) is known to transform most immortal cells but to induce
premature senescence in primary cells. RAS V12-induced senescence in murine cells …

Publisher Summary This chapter discusses the complex regulatory region of SV40. It may
serve as a model of the regulatory mechanisms that operate in many other eukaryotic …

The mammalian transcription factor LSF (CP2/LBP-1c) binds cellular promoters modulated
by cell growth signals. We demonstrate here that LSF-DNA-binding activity is strikingly …

Distinct signalling pathways producing diverse cellular outcomes can utilize similar subsets
of proteins. For example, proteins from the TCR (T-cell receptor) ESC (early signalling …

Simian virus 40 (SV40) large T antigen is a promiscuous transcriptional activator of many
viral and cellular promoters. The SV40 late promoter, a primary target for T-antigen …

Whereas large T antigen (LT) of simian virus 40 (SV40) promotes oncogenesis by
inactivating the tumor suppressor proteins p53 and pRb, SV40 small T antigen (ST) has …

p62 is a recently identified ubiquitin-binding, cytosolic phosphoprotein that interacts with
several signal transduction molecules including the tyrosine kinase p56 lck and the protein …

DNA tumor viruses such as simian virus 40 (SV40) express dominant acting oncoproteins
that exert their effects by associating with key cellular targets and altering the signaling …

Although the small DNA tumor virus SV40 (simian virus 40) fails to replicate in human cells,
understanding how SV40 transforms human and murine cells has and continues to provide …

Simian virus 40 (SV40) large T antigen (TAg) is a multifunctional oncoprotein essential for
productive viral infection and for cellular transformation. We have used microarray analysis …