[HTML][HTML] Calcium-activated potassium current: a novel ion channel candidate in atrial fibrillation

S Nattel - The Journal of physiology, 2009 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most common clinical arrhythmia, and an important contributor to
cardiovascular morbidity and mortality (Kannel & Benjamin, 2008). Currently available …

Cardiac ion channels and mechanisms for protection against atrial fibrillation

M Grunnet, BH Bentzen, US Sørensen… - Reviews of Physiology …, 2012 - Springer
Atrial fibrillation (AF) is recognised as the most common sustained cardiac arrhythmia in
clinical practice. Ongoing drug development is aiming at obtaining atrial specific effects in …

Ionic Determinants of Atrial Fibrillation and Ca2+ Channel Abnormalities: Cause, Consequence, or Innocent Bystander?

S Nattel - Circulation research, 1999 - Am Heart Assoc
Over the past several years, there has been increasing interest in understanding the basic
mechanisms underlying atrial fibrillation (AF). The rise in interest is partly related to the …

Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog

XY Qi, JG Diness, BJJM Brundel, XB Zhou, P Naud… - Circulation, 2014 - Am Heart Assoc
Background—Recent evidence points to functional Ca2+-dependent K+ (SK) channels in
the heart that may govern atrial fibrillation (AF) risk, but the underlying mechanisms are …

Calcium handling and atrial fibrillation

J Heijman, N Voigt, S Nattel, D Dobrev - Wiener Medizinische …, 2012 - Springer
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical
setting. It is associated with substantial cardiovascular morbidity and mortality. Recent …

Calcium dysregulation in atrial fibrillation: the role of CaMKII

J Heijman, N Voigt, XHT Wehrens… - Frontiers in …, 2014 - frontiersin.org
Atrial fibrillation (AF) is the most frequently encountered clinical arrhythmia and is associated
with increased morbidity and mortality. Ectopic activity and reentry are considered major …

The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities

S Nattel, D Dobrev - European heart journal, 2012 - academic.oup.com
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …

Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation

J Heijman, X Zhou, S Morotti, CE Molina… - Circulation …, 2023 - Am Heart Assoc
Background: Small-conductance Ca2+-activated K+ (SK)–channel inhibitors have
antiarrhythmic effects in animal models of atrial fibrillation (AF), presenting a potential novel …

[HTML][HTML] Role of calcium-activated potassium channels in atrial fibrillation pathophysiology and therapy

JG Diness, BH Bentzen, US Sørensen… - Journal of …, 2015 - journals.lww.com
Small-conductance Ca 2+-activated potassium (SK) channels are relative newcomers within
the field of cardiac electrophysiology. In recent years, an increased focus has been given to …

Effect of antiarrhythmic drugs on small conductance calcium–activated potassium channels

R Simó-Vicens, DRP Sauter, M Grunnet… - European Journal of …, 2017 - Elsevier
Atrial fibrillation (AF) is the most common type of arrhythmia. Current pharmacological
treatment for AF is moderately effective and/or increases the risk of serious ventricular …