Evidence for two distinct perceptual alterations in irritable bowel syndrome

BD Naliboff, J Munakata, S Fullerton, RH Gracely… - Gut, 1997 - gut.bmj.com
Background and aims—Visceral hyperalgesia has been implicated as a factor contributing
to symptom generation in irritable bowel syndrome (IBS). However, previous studies using …

Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity

SD Dorn, OS Palsson, SIM Thiwan, M Kanazawa… - Gut, 2007 - gut.bmj.com
Objective: The aim was to determine whether lower visceral pain thresholds in irritable
bowel syndrome (IBS) primarily reflect physiological or psychological factors. Methods …

Altered rectal perception in irritable bowel syndrome is associated with symptom severity

I Posserud, A Syrous, L Lindström, J Tack… - Gastroenterology, 2007 - Elsevier
Background & Aims: Diverging results exist regarding the connection between altered
visceral perception and gastrointestinal (GI) symptoms, as well as the effects of …

Altered rectal perception is a biological marker of patients with irritable bowel syndrome

H Mertz, B Naliboff, J Munakata, N Niazi, EA Mayer - Gastroenterology, 1995 - Elsevier
Background & Aims: Lowered visceral perception thresholds have been suggested as a
biological marker of irritable bowel syndrome (IBS). The current study sought to determine …

Symptom severity but not psychopathology predicts visceral hypersensitivity in irritable bowel syndrome

PPJ Van der Veek, YR Van Rood… - Clinical Gastroenterology …, 2008 - Elsevier
Background & Aims: Visceral hypersensitivity is a hallmark of irritable bowel syndrome (IBS),
but the relationship with clinical symptoms and psychological factors has not been fully …

Correlation of symptom criteria with perception thresholds during rectosigmoid distension in irritable bowel syndrome patients

M Schmulson, L Chang, B Naliboff… - Official journal of the …, 2000 - journals.lww.com
OBJECTIVE: Due to a lack of reliable biological markers, the diagnosis of irritable bowel
syndrome (IBS) is based on symptom criteria. The possible physiological correlates of these …

Symptoms and visceral perception in patients with pain-predominant irritable bowel syndrome

T Lembo, B Naliboff, J Munakata… - Official journal of the …, 1999 - journals.lww.com
Objective: Abdominal pain is thought to be a hallmark of the irritable bowel syndrome (IBS),
although currently used symptom criteria do not differentiate between abdominal pain and …

Perceptual responses in patients with inflammatory and functional bowel disease

L Chang, J Munakata, EA Mayer, MJ Schmulson… - Gut, 2000 - gut.bmj.com
BACKGROUND AND AIMS Enhanced visceral sensitivity following a transient inflammatory
process in the gut has been postulated as an aetiological mechanism of irritable bowel …

Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Methods to assess visceral hypersensitivity in irritable bowel syndrome

D Keszthelyi, FJ Troost… - American Journal of …, 2012 - journals.physiology.org
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder,
characterized by recurrent abdominal pain or discomfort in combination with disturbed …

Relationship between symptoms and hypersensitivity to rectal distension in patients with irritable bowel syndrome

SD Kuiken, R Lindeboom, GN Tytgat… - Alimentary …, 2005 - Wiley Online Library
Background: Visceral hypersensitivity is considered an important pathophysiological
mechanism in irritable bowel syndrome, yet its relationship to symptoms is unclear. Aim: To …