There are two basic categories of pain: physiological pain, which serves an important
protective function, and pathological pain, which can have a major negative impact on …

Pain is necessary for survival, but persistent pain can result in anxiety, depression and a
reduction in the quality of life. The discriminative and affective qualities of pain are both …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Neuropathic pain is currently being treated by a range of therapeutic interventions that
above all act to lower neuronal activity in the somatosensory system (eg using local …

Pain is a fundamental experience with a complex and multi-layered neurobiological basis. In
recent years a powerful battery of techniques has been brought to bear to unravel the …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …

During evolution, living organisms develop a specialized apparatus called nociceptors to
sense their environment and avoid hazardous situations. Intense stimulation of high …

Advances in the characterization of pain signaling in recent years indicate that distinct
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …

Pain is a fundamental and central life experience, a counterbalance to pleasure, a warning
of danger, and a reminder to guard injured limbs and tissues while they heal. And yet …

Nociception provides a means of neural feedback that allows the central nervous system
(CNS) to detect and avoid noxious and potentially damaging stimuli in both active and …