Pain research has uncovered important neuronal mechanisms that underlie clinically
relevant pain states such as inflammatory and neuropathic pain. Importantly, both the …

The molecular/genetic era has seen the discovery of a staggering number of molecules
implicated in pain mechanisms [18],[35],[61],[69],[96],[133],[150],[202],[224]. This has …

Chronic pain is a major challenge to clinical practice and basic science. The peripheral and
central neural networks that mediate nociception show extensive plasticity in pathological …

Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …

Persistent or chronic pain is the primary reason people seek medical care, yet current
therapies are either inadequate for certain types of pain or cause intolerable side effects …

Chronic pain is a disabling disease with limited treatment options. While animal models
have revealed important aspects of pain neurobiology, therapeutic translation of this …

The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …

An important property of the nociceptive system is its plasticity, ie, the ability to change in an
experience-dependent manner, which is implicated in the transition from acute pain to …

Our understanding of chronic inflammatory and neuropathic pain at the molecular and
cellular level has developed at an extraordinary rate in recent years. Inflammatory, or …

Conditioned pain modulation is a powerful analgesic mechanism, occurring when a painful
stimulus is inhibited by a second painful stimulus delivered at a different body location …