Facets and mechanisms of adaptive pain behavior: predictive regulation and action
Neural mechanisms underlying nociception and pain perception are considered to serve the
ultimate goal of limiting tissue damage. However, since pain usually occurs in complex …
ultimate goal of limiting tissue damage. However, since pain usually occurs in complex …
Nociceptors—noxious stimulus detectors
CJ Woolf, Q Ma - Neuron, 2007 - cell.com
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
Nucleotide signaling and cutaneous mechanisms of pain transduction
Sensory neurons that innervate the skin provide critical information about physical contact
between the organism and the environment, including information about potentially …
between the organism and the environment, including information about potentially …
Exploring pain pathophysiology in patients
C Sommer - Science, 2016 - science.org
Although animal models of pain have brought invaluable information on basic processes
underlying pain pathophysiology, translation to humans is a problem. This Review will …
underlying pain pathophysiology, translation to humans is a problem. This Review will …
Mechanisms of chronic pain
JA Markenson - The American journal of medicine, 1996 - Elsevier
Chronic pain differs from acute pain in that it serves no useful function, causes suffering,
limits activities of daily living, and increases costs of healthcare payments, disability, and …
limits activities of daily living, and increases costs of healthcare payments, disability, and …
[HTML][HTML] The search for novel analgesics: targets and mechanisms
TL Yaksh, SA Woller, R Ramachandran… - F1000prime …, 2015 - ncbi.nlm.nih.gov
The management of the pain state is of great therapeutic relevance to virtually every medical
specialty. Failure to manage its expression has deleterious consequence to the well-being …
specialty. Failure to manage its expression has deleterious consequence to the well-being …