Neural mechanisms underlying nociception and pain perception are considered to serve the
ultimate goal of limiting tissue damage. However, since pain usually occurs in complex …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Sensory neurons that innervate the skin provide critical information about physical contact
between the organism and the environment, including information about potentially …

Although animal models of pain have brought invaluable information on basic processes
underlying pain pathophysiology, translation to humans is a problem. This Review will …

Chronic pain differs from acute pain in that it serves no useful function, causes suffering,
limits activities of daily living, and increases costs of healthcare payments, disability, and …

The management of the pain state is of great therapeutic relevance to virtually every medical
specialty. Failure to manage its expression has deleterious consequence to the well-being …