Streptozotocin (STZ)-induced diabetes in the rat has been increasingly used as a model of
painful diabetic neuropathy to assess the efficacies of potential analgesic agents. We have …

Painful peripheral neuropathy is a common secondary complication of diabetes. The
streptozotocin (STZ)‐induced diabetic rat is the most commonly employed animal model …

The procedures to induce insulin-deficient diabetes in rats using streptozotocin are
described along with a number of insulin treatment regimes that can be used to maintain …

This study used streptozotocin (STZ; 50 mg/kg ip) diabetic rats and monitored weekly
thermal and mechanical nociceptive thresholds for 8 weeks diabetes. Rats developed …

Painful diabetic neuropathy is one of the most common complications of insulin-dependent
diabetes in man. Conflicting results have been obtained in experimentally diabetic animals …

A modified von Frey filament test and an algesiometer paw pressure test were used to
measure mechanical nociceptive withdrawal thresholds of the hind limb of control rats and …

The triggers and pathogenesis of peripheral diabetic neuropathy are poorly understood, and
this study evaluated the role of insulinopenia in nociceptive abnormalities in the …

The streptozocin-induced diabetic rat has been put forward as a model of chronic pain with
signs of hyperalgesia and allodynia that may reflect signs observed in diabetic humans. The …

The present study was designed to investigate the anti-allodynic effects of current analgesic
agents, such as pregabalin, amitriptyline, mexiletine, morphine, and diclofenac, in a rat …

Hyperactivity of nociceptive C-fibers has been recently described in diabetic BB/Wistar rats.
This study assesses the association of hyperalgesia, using an analgesy-meter, with elevated …