EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

ZY Chen, WZ Zhong, XC Zhang, J Su, XN Yang… - The …, 2012 - academic.oup.com
Background. Non-small cell lung cancer patients with epidermal growth factor receptor
(EGFR) mutations have mixed responses to tyrosine kinase inhibitors (TKIs). Intertumor …

[HTML][HTML] Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small …

CH Gow, YL Chang, YC Hsu, MF Tsai, CT Wu, CJ Yu… - Annals of …, 2009 - Elsevier
Background Mutations of the epidermal growth factor receptor (EGFR) gene in non-small-
cell lung cancer (NSCLC) patients predict the patients who will respond to EGFR tyrosine …

High concordance of EGFR mutation status between histologic and corresponding cytologic specimens of lung adenocarcinomas

PL Sun, Y Jin, H Kim, CT Lee, S Jheon… - Cancer …, 2013 - Wiley Online Library
BACKGROUND Activating mutations in the epidermal growth factor receptor (EGFR) in non–
small cell lung carcinoma (NSCLC) are associated significantly with responsiveness to …

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib

K Taniguchi, J Okami, K Kodama… - Cancer …, 2008 - Wiley Online Library
Somatic mutations introduced into the epidermal growth factor receptor (EGFR) gene in non‐
small‐cell lung cancer (NSCLC) are important factors to determine therapeutic responses to …

[HTML][HTML] Complex mutations in the epidermal growth factor receptor gene in non-small cell lung cancer

A Hata, H Yoshioka, S Fujita, K Kunimasa, R Kaji… - Journal of Thoracic …, 2010 - Elsevier
Introduction: Mutation of the epidermal growth factor receptor (EGFR) gene can predict the
efficacy of EGFR-tyrosine kinase inhibitors. Different mutations have been shown to co-occur …

[HTML][HTML] An alternative method for screening EGFR mutation using RFLP in non-small cell lung cancer patients

I Kawada, K Soejima, H Watanabe, I Nakachi… - Journal of Thoracic …, 2008 - Elsevier
Introduction Epidermal growth factor receptor (EGFR) mutations are strong determinants of
tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancers (NSCLCs) …

[HTML][HTML] Uncommon EGFR mutations in lung adenocarcinoma: features and response to tyrosine kinase inhibitors

A Brindel, W Althakfi, M Barritault, E Watkin… - Journal of Thoracic …, 2020 - ncbi.nlm.nih.gov
Background EGFR mutant non-small cell lung cancer (NSCLC) is a heterogeneous disease.
The treatment for frequent EGFR mutations relies on tyrosine kinase inhibitors (TKIs); the …

Good Response to Gefitinib in Lung Adenocarcinoma of Complex Epidermal Growth Factor Receptor (EGFR) Mutations with the Classical Mutation Pattern

SG Wu, YL Chang, YC Hsu, JY Wu, CH Yang… - The …, 2008 - academic.oup.com
Background. Epidermal growth factor receptor (EGFR) mutations are usually detected in
lung adenocarcinoma and are associated with a response to EGFR tyrosine kinase …

[HTML][HTML] Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors

S Kobayashi, HM Canepa, AS Bailey… - Journal of Thoracic …, 2013 - Elsevier
Background: Non–small-cell lung cancers (NSCLCs) containing EGFR mutations are
exquisitely sensitive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …

[HTML][HTML] Mutational analysis in cytological specimens of advanced lung adenocarcinoma: a sensitive method for molecular diagnosis

L Boldrini, S Gisfredi, S Ursino, T Camacci… - Journal of Thoracic …, 2007 - Elsevier
Introduction The discovery that somatic mutations in the epidermal growth factor receptor
(EGFR) gene are associated with sensitivity to the EGFR tyrosine kinase inhibitors (TKIs) in …