Heterocyclic thiosemicarbazones, thioureas and 2-substituted pyridine N-oxides as well as
representative nickel, cobalt and copper complexes were shown to be potent antineoplastic …

The prognosis for patients with metastatic melanoma remains very poor. Constitutive signal
transducer and activator of transcription 3 (STAT3) activation has been correlated to …

Melanoma is the most aggressive skin cancer, and its incidence has continued to rise during
the past decades. Conventional treatments present severe side effects in cancer patients …

CC-115 is a dual inhibitor of the mechanistic target of rapamycin (mTOR) kinase and the
DNA-dependent protein kinase (DNA-PK) that is currently being studied in phase I/II clinical …

Malignant melanoma is the major cause of death from skin cancer. Treatment of metastatic
melanoma remains an enormous challenge. In this study we developed hybrid compounds …

The current clinical interventions in malignant melanomas are met with poor response to
therapy due to dynamic regulation of multiple melanoma signaling pathways consequent to …

Melanoma is a very aggressive type of skin cancer. Mutation in BRAF and NRAS are often
found in patients with this disease. Therefore, in recent years the search for new molecules …

A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five
S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative …

A series of substituted N-(2, 3, 4, 6-tetra-O-acetyl-β-d-galactopyranosyl) thiosemicarbazones
5a–5j of substituted 3-acetylcoumarins were synthesized with yields of 45–68%. All …

In this study, firstly, 22 thiosemicarbazone derivatives (3a-y) were synthesized. Then, ADME
parameters, pharmacokinetic properties, drug-like structures, and suitability for medicinal …