Novel thiosemicarbazone and thiazolidin‐4‐one derivatives containing vanillin core: Synthesis, characterization, and anticancer activity studies
Cancer is one of the most common and lethal disease in the world, therefore, patients need
new and potent anticancer agents for treatment. In this study, starting from vanillin, 24 new …
new and potent anticancer agents for treatment. In this study, starting from vanillin, 24 new …
[HTML][HTML] N4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: cytotoxicity against human tumor cells, structure–activity relationship studies and investigation on …
MA Soares, JA Lessa, IC Mendes, JG Da Silva… - Bioorganic & medicinal …, 2012 - Elsevier
N4-Phenyl 2-acetylpyridine thiosemicarbazone (H2Ac4Ph; N-(phenyl)-2-(1-(pyridin-2-yl)
ethylidene) hydrazinecarbothioamide) and its N4-ortho-,-meta-and-para-fluorophenyl …
ethylidene) hydrazinecarbothioamide) and its N4-ortho-,-meta-and-para-fluorophenyl …
Synthesis, molecular docking, and apoptogenic efficacy of novel N-heterocycle analogs to target B-cell lymphoma 2/X-linked inhibitors of apoptosis proteins to regress …
Z Zabiulla, VH Malojirao, YHE Mohammed… - Medicinal Chemistry …, 2019 - Springer
The novel series of piperidine conjugated benzophenone analogs with amide link 11a–l
were synthesized in a multistep process. The structures of these compounds were confirmed …
were synthesized in a multistep process. The structures of these compounds were confirmed …
[HTML][HTML] Design and synthesis of novel N (4)-substituted thiosemicarbazones bearing a pyrrole unit as potential anticancer agents
T Zhu, S Shen, Q Lu, X Ye, W Ding… - Oncology …, 2017 - spandidos-publications.com
Abstract A series of N (4)-substituted thiosemicarbazones (TSCs) bearing pyrrole unit (1a‑
1e) were synthesized and fully characterized by elemental analyses, infrared spectra, 1H …
1e) were synthesized and fully characterized by elemental analyses, infrared spectra, 1H …
[HTML][HTML] Synthesis, structural elucidation and cytotoxicity of new thiosemicarbazone derivatives
Abstract Syntheses and characterization (1 H & 13 C NMR and CHN) of four new
thiosemicarbazone derivatives (1–4) are reported. The molecular structures of compounds 1 …
thiosemicarbazone derivatives (1–4) are reported. The molecular structures of compounds 1 …
Anti-metastatic and anti-angiogenic properties of potential new anti-cancer drugs based on metal complexes of selenosemicarbazones
Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-
formylpyridine selenosemicarbazone induce apoptosis in cancer cells via activation of …
formylpyridine selenosemicarbazone induce apoptosis in cancer cells via activation of …
[HTML][HTML] Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
H Karlsson, M Fryknäs, S Strese, J Gullbo… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit
compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We …
compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We …
Novel anticancer compounds induce apoptosis in melanoma cells
UG Bhat, PA Zipfel, DS Tyler, AL Gartel - Cell cycle, 2008 - Taylor & Francis
We previously described the identification of a nucleoside analog transcriptional inhibitor
ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-Pyrrolo [2, 3-d]-pyrimidine-5 …
ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-Pyrrolo [2, 3-d]-pyrimidine-5 …
[HTML][HTML] Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first …
V Sestak, J Stariat, J Cermanova, E Potuckova… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Di (2-pyridyl) ketone 4, 4-dimethyl-3-thiosemicarbazone (Dp44mT) and di (2-
pyridyl) ketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) are novel, highly potent …
pyridyl) ketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) are novel, highly potent …
[HTML][HTML] Characterization of the anticancer effects of S115, a novel heteroaromatic thiosemicarbazone compound, in vitro and in vivo
M Liu, L Xiao, Y Dong, Y Liu, L Cai, W Xiong… - Acta pharmacologica …, 2014 - nature.com
Aim: To investigate the anticancer effects of S115, a novel heteroaromatic
thiosemicarbazone compound in vitro and in vivo. Methods: The anti-proliferative action of …
thiosemicarbazone compound in vitro and in vivo. Methods: The anti-proliferative action of …