Insulin increased the maximal rate of sugar transport in the perfused rat heart, but had
essentially no effect on the Michaelis constant of sugar entry or half-maximal constant for …

The effect of insulin on glucose transport and glucose transporters was studied in perfused
rat heart. Glucose transport was measured by the efflux of labelled 3-O-methylglucose from …

The possibility that the action of insulin involves the permeability of muscle cells to sugars
(reviewed by Levine & Goldstein, 1955) has led to a number of investigations on the kinetics …

Calcium-tolerant myocytes from the adult rat heart were used to study the effects of insulin
on the kinetics of myocardial 3-0-methylglucose transport at 37 degrees C. Insulin increased …

RESULTS Effect of Growth Hormone in Vitro-Glucose uptake by the heart from normal rats
was not affected when growth hormone was added directly to the perfusion medium (Fig. 1) …

RESULTS Glucose Uptake without and with Added Ins&z-The glucose uptake by hearts of
hypophysectomized rats at various perfusate glucose concentrations is shown in Table II …

The stimulation of glucose uptake by muscle cells is recognized as one of the most important
and characteristic actions of insulin. This hormone effect was shown in earlier work (1, 2) to …

1. The entry of glucose into the pectoralis major muscle of living rats was measured over a
wide range of plasma glucose concentrations. A technique was used by which steady …

The mechanism of insulin action on glucose transport in rat hearts was studied. The glucose
transport activity was determined after reconstitution into egg lecithin liposomes. Isolated rat …

RESULTS General Considerations-Transport and phosphorylation activities could be
assessed as follows. Details are given elsewhere (4-6). The uptake of glucose from the …