Autophagy as a molecular target for cancer treatment
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …
Understanding the role of autophagy in cancer formation and progression is a real opportunity to treat and cure human cancers
Simple Summary The modulation of autophagy represents a potential therapeutic strategy
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …
for cancer. More than one hundred clinical trials have been conducted or are ongoing to …
Autophagy and cancer: Basic mechanisms and inhibitor development
Y Hama, Y Ogasawara, NN Noda - Cancer Science, 2023 - Wiley Online Library
Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …
Autophagy modulation as a target for anticancer drug discovery
X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …
Autophagy in tumor suppression and cancer therapy
CP Kung, A Budina, G Balaburski… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Autophagy is a stress-induced cell survival program whereby cells under metabolic,
proteotoxic, or other stress remove dysfunctional organelles and/or misfolded …
proteotoxic, or other stress remove dysfunctional organelles and/or misfolded …
Molecular mechanisms of autophagy in cancer development, progression, and therapy
VAM Vitto, S Bianchin, AA Zolondick, G Pellielo… - Biomedicines, 2022 - mdpi.com
Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …
important role in maintaining cellular homeostasis. It involves regulation of various genes …
Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress
Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications
Z Bai, Y Peng, X Ye, Z Liu, Y Li, L Ma - Journal of Zhejiang University …, 2022 - Springer
Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …
treatment, but the complex biological processes of cancer cells seriously limit the efficacy of …
Autophagy in cancer: recent advances and future directions
Autophagy is being explored as a potential therapeutic target for enhancing the cytotoxic
effects of chemotherapeutic regimens in various malignancies. Autophagy plays a very …
effects of chemotherapeutic regimens in various malignancies. Autophagy plays a very …