Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Macroautophagy/autophagy is a fundamental cellular degradation mechanism that
maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in …

Non-apoptotic forms of programmed cell death are targets for novel approaches in
anticancer therapy. Indeed, cancer cells often present with mutations in the apoptotic …

Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an
intracellular catabolic degradative process targeting damaged and superfluous cellular …

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Autophagy is a dynamic process involving the bulk degradation of cytoplasmic organelles
and proteins. Based on the function of “cellular recycling”, autophagy plays key roles in the …

Autophagy, or cellular self-digestion, is activated in cancer cells in response to multiple
stresses and has been demonstrated to promote tumor cell survival and drug resistance …

Autophagy is a highly regulated catabolic process that involves lysosomal degradation of
proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis …