LNA-modified oligonucleotides mediate specific inhibition of microRNA function

UA Ørom, S Kauppinen, AH Lund - Gene, 2006 - Elsevier
microRNAs are short, endogenous non-coding RNAs that act as post-transcriptional
modulators of gene expression. Important functions for microRNAs have been found in the …

An LNA-based loss-of-function assay for micro-RNAs

I Naguibneva, M Ameyar-Zazoua, N Nonne… - Biomedicine & …, 2006 - Elsevier
MicroRNAs (miRNAs) have recently emerged as being essential for development and for the
control of cell proliferation/differentiation in various organisms. However, little is known …

MicroRNAs as targets for antisense-based therapeutics

J Stenvang, S Kauppinen - Expert opinion on biological therapy, 2008 - Taylor & Francis
MicroRNAs (miRNAs) are a novel class of endogenous non-coding single-stranded RNAs,
which regulate gene expression post-transcriptionally by base pairing with their target …

MicroRNA silencing in primates: towards development of novel therapeutics

A Petri, M Lindow, S Kauppinen - Cancer research, 2009 - AACR
MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as
important posttranscriptional regulators of gene expression. Accumulating evidence …

Inhibition of microRNA with antisense oligonucleotides

CC Esau - Methods, 2008 - Elsevier
Antisense inhibition of microRNA (miRNA) function has been an important tool for
uncovering miRNA biology. Chemical modification of anti-miRNA oligonucleotides (AMOs) …

Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells

MD Horwich, PD Zamore - Nature protocols, 2008 - nature.com
Abstract MicroRNAs (miRNAs),∼ 22-nt RNAs that mediate post-transcriptional regulation of
mRNAs in animals and plants, are a diverse class of regulatory genes whose specific …

MicroRNA therapeutics: a new niche for antisense nucleic acids

SM Hammond - Trends in molecular medicine, 2006 - cell.com
MicroRNA molecules (miRNAs) are naturally occurring triggers of the RNA-interference
pathway. The first identified miRNA, lin-4, was discovered in Caenorhabditis elegans> 20 …

microRNAs: a new emerging class of players for disease diagnostics and gene therapy

B Zhang, MA Farwell - Journal of cellular and molecular …, 2008 - Wiley Online Library
• Introduction‐Brief history, biogenesis and the regulated mechanism of miRNAs• Roles of
miRNAs in human disease and miRNAs as a novel biomarker for cancer and disease …

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?

J Weiler, J Hunziker, J Hall - Gene therapy, 2006 - nature.com
Abstract MicroRNAs (miRNAs) are endogenous 19–25 nucleotide RNAs that have recently
emerged as a novel class of important gene-regulatory molecules involved in many critical …

Therapeutic potential for microRNAs

CC Esau, BP Monia - Advanced drug delivery reviews, 2007 - Elsevier
MiRNAs are a conserved class of non-coding RNAs that negatively regulate gene
expression post-transcriptionally. Although their biological roles are largely unknown …