The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires
that uncommitted progenitors successfully negotiate the transition from multipotency to …

The development of B cells from haematopoietic stem cells proceeds along a highly
ordered, yet flexible, pathway. At multiple steps along this pathway, cells are instructed by …

Genetic networks that regulate B lymphopoiesis : Current Opinion in Hematology Genetic
networks that regulate B lymphopoiesis : Current Opinion in Hematology Log in or Register …

B cell development is a multistep process that is tightly regulated at the transcriptional level.
In recent years, investigators have shed light on the transcription factor networks involved in …

All mature blood cells derive from hematopoietic stem cells through gradual restriction of
their cell fate potential and acquisition of specialized functions. Lineage specification and …

Powerful techniques—including gene targeting, genomic and proteomic analyses—are
allowing a more complete understanding of the transcription factors that drive B-cell …

The B cell developmental pathway represents a leading system for the analysis of regulatory
circuits that orchestrate cell fate specification, commitment, and differentiation. We review the …

Although B lymphopoiesis is one of the best-defined paradigms in cell differentiation, our
knowledge of the regulatory mechanisms underlying its earliest processes, in which …

Background Signaling via B cell receptor (BCR) and Toll-like receptors (TLRs) results in
activation of B cells with distinct physiological outcomes, but transcriptional regulatory …

Hematopoiesis is regulated by signals from the microenvironment, transcription factor
networks, and changes of the epigenetic landscape. Transcription factors interact with and …