B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a rare aggressive malignancy
in adults. BCP-ALL is frequently characterized by recurrent chromosomal translocations that …

An increasing number of evidences suggest a genetic predisposition in acute lymphoblastic
leukemia (ALL) that might favor the occurrence of the driver genetic alterations. Such genetic …

The mutational landscape of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the
most common pediatric cancer, is not fully described partially because commonly applied …

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a
leading case of childhood cancer death. The last decade has witnessed a transformation in …

Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the
outcome after relapse is poor. To understand the genetic events that contribute to relapse …

Recent efforts reclassified B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) into
more refined subtypes. Nevertheless, outcomes of relapsed BCP-ALL remain unsatisfactory …

The development of effective therapy for children with acute lymphoblastic leukemia is one
of the great successes of clinical hematology andoncology. Fifty years ago, childhood acute …

CR: complete response; SCT: stem cell transplantation. aRemaining BCP-ALL group
contains eight cases with high-hyperdiploidy (50-62 chromosomes), three TCF3-PBX1 …

Abstract The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-
Frankfurt-Münster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the …

Abstract Background: The 5-year event-free survival of pediatric precursor-B acute
lymphoblastic leukemia (BCP-ALL) has currently reached 80-90%. Targeted drugs are …