Over the past 30 years, the striking improvements in the survival rates of patients with
childhood cancers are due, in large part, to the use of aggressive treatment strtegies. These …

York. Division of Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles,
California. Division of Pediatric Endocrinology, Memorial Sloan-Kettering Cancer Center …

Contemporary pediatric oncology is defined by its increased use of “risk-based” cancer
therapy that endeavors to deliver effective antineoplastic treatment with reduced toxicity to …

Improved treatment and supportive care have increased the survival of children diagnosed
with cancer. This success has resulted in a growing population at risk of long-term …

During the past three decades, multi-modality therapy for childhood cancer has resulted in
markedly improved survival. For the period of 1985 to 1997, the fiveyear survival rate for …

Incremental improvements in the treatment of children and adolescents with cancer have led
to 5-year survival rates reaching nearly 85%. In the past decade, impressive progress has …

The December 2004 Food and Drug Administration (FDA) approval of clofarabine (Clolar,
Genzyme) for refractory pediatric acute lymphoblastic leukemia was a milestone in the …

Regardless of how one defines survivorship, more than 10 million individuals in the United
States have been treated for a malignant disease; about 250,000 were younger than 21 …

More than 70% of childhood cancer is now curable with best modern therapy. The treatment
is expensive but in terms of cost per life year saved, USD 1750, compares very favourably …

There was a time when success in the treatment of childhood cancer was measured in terms
of survival alone. However, as the survival rates have risen steadily, so attention has turned …