Nutrigenomics, the microbiome, and gene-environment interactions: new directions in cardiovascular disease research, prevention, and treatment: a scientific …

JF Ferguson, H Allayee, RE Gerszten… - Circulation …, 2016 - Am Heart Assoc
Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked
to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple …

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

F Asnicar, SE Berry, AM Valdes, LH Nguyen… - Nature medicine, 2021 - nature.com
The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

[HTML][HTML] Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment

BA Kappel, L De Angelis, M Heiser, M Ballanti… - Molecular …, 2020 - Elsevier
Objective The metabolic influence of gut microbiota plays a pivotal role in the pathogenesis
of cardiometabolic diseases. Antibiotics affect intestinal bacterial diversity, and long-term …

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

DD Wang, LH Nguyen, Y Li, Y Yan, W Ma, E Rinott… - Nature medicine, 2021 - nature.com
To address how the microbiome might modify the interaction between diet and
cardiometabolic health, we analyzed longitudinal microbiome data from 307 male …

[HTML][HTML] The gut microbiota (microbiome) in cardiovascular disease and its therapeutic regulation

MM Rahman, F Islam, MH -Or-Rashid… - Frontiers in cellular …, 2022 - frontiersin.org
In the last two decades, considerable interest has been shown in understanding the
development of the gut microbiota and its internal and external effects on the intestine, as …

The gut microbiome as novel cardio-metabolic target: the time has come!

S Vinjé, E Stroes, M Nieuwdorp… - European heart …, 2014 - academic.oup.com
Recent studies reveal a potential contribution of intestinal microbes in the expression of
certain human cardio-metabolic diseases. The mechanisms through which intestinal …

Gut microbiota in cardiovascular health and disease

WHW Tang, T Kitai, SL Hazen - Circulation research, 2017 - Am Heart Assoc
Significant interest in recent years has focused on gut microbiota–host interaction because
accumulating evidence has revealed that intestinal microbiota play an important role in …

Intestinal Microbiota in Cardiovascular Health and Disease: JACC State-of-the-Art Review

WHW Tang, F Bäckhed, U Landmesser… - Journal of the American …, 2019 - jacc.org
Despite major strides in reducing cardiovascular disease (CVD) burden with modification of
classic CVD risk factors, significant residual risks remain. Recent discoveries that linked …

The emerging role of gut microbial metabolism on cardiovascular disease

K Kasahara, FE Rey - Current opinion in microbiology, 2019 - Elsevier
Highlights•Clinical cohorts show associations between gut microbiome and CVD.•Products
of microbial metabolism derived from diet are linked with progression of CVD.•Microbes are …

[HTML][HTML] Metabolome–microbiome crosstalk and human disease

KA Lee-Sarwar, J Lasky-Su, RS Kelly, AA Litonjua… - Metabolites, 2020 - mdpi.com
In this review, we discuss the growing literature demonstrating robust and pervasive
associations between the microbiome and metabolome. We focus on the gut microbiome …