Purpose Lysophosphatidic acid (LPA) exerts various physiological and pathological effects
by activating its distinct G-protein-coupled LPA receptors. We demonstrated that LPA can …

Background Lysophosphatidic acid (LPA) and its receptors play a key role in regulating
cancer progression. Upregulation of LPA receptor 2 (LPAR2) plays a role in carcinogenesis; …

Current studies have demonstrated that significant increased LPA levels to be observed in
ascites in patients with ovarian cancer. Although several studies have shown that …

LPAR6 is the most recently determined G-protein-coupled receptor of the lysophosphatidic
acid receptor, and very few of studies have demonstrated the performance of LPAR6 in …

Background Lysophosphatidic acid receptor 3 (LPAR3) is coupled to G α i/o and G α 11/q
signaling. Previously, we reported that LPAR3 is highly methylated in carcinogen-induced …

Muscle invasive bladder carcinoma is a highly malignant cancer with a high mortality rate,
due to its tendency to metastasize. The tyrosine kinase recepteur d'origine nantais (RON) …

Abstract Background and Objective Lysophosphatidic acid (LPA) has widely been reported
to participate in the numerous biological behaviors of tumors through its receptors. LPA …

Abstract Background Lysophosphatidic acids (LPAs) belong to a class of bioactive
lysophospholipids with multiple functions including immunomodulatory roles in tumor …

Prostate cancer is a common malignancy in men worldwide. Lysophosphatidic acid receptor
1 (LPAR1) is a critical gene and it mediates diverse biologic functions in tumor. However, the …

Lysophosphatidic acid (LPA) is an extracellular biological lipid which interacts with G protein-
coupled LPA receptors (LPA 1 to LPA 6). LPA signaling via LPA receptors mediates several …