Since their initial discovery in yeast, cyclin-dependent kinases have proven to be universal
regulators of the cell cycle in all eukaryotes. In unicellular eukaryotes, cell cycle progression …

The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …

Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks).
Phosphorylation of specific targets by cyclin–Cdk complexes sets in motion different …

Cyclin-dependent kinase (CDK) activity is essential for eukaryotic cell cycle events. Multiple
cyclins activate CDKs in all eukaryotes, but it is unclear whether multiple cyclins are really …

Cyclin‐dependent kinases and their regulatory subunits, the cyclins, are known to regulate
progression through the cell cycle. Yet these same proteins are often expressed in non …

INTRODUCTION Cyclins are the activating partners of a highly conserved family of
proteinkinases, the cyclin-dependent kinases (CDKs). A number of diverse cyclins and …

Cyclins and cyclin-dependent kinases (Cdks) are universal regulators of cell cycle
progression in eukaryotic cells. Cdk activity is controlled by phosphorylation at three …

Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent
kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a …

ABSTRACT A significant portion of cellular scientific literature published is dedicated to
describing the cloning, the link to cancer, or the characterization of proteins involved in the …