The formation of the atherosclerotic plaque that is characterized by the accumulation of
abnormal amounts of cholesterol-loaded macrophages in the artery wall is mediated by both …

High-density lipoprotein (HDL) particles transport (among other molecules) cholesterol (HDL-
C). In epidemiological studies, plasma HDL-C levels have an inverse relationship to the risk …

Several prospective epidemiological studies have shown that there is a clear inverse
relationship between serum high-density lipoprotein-cholesterol (HDL-C) concentrations …

High-density lipoproteins (HDLs) have been well established to protect against the
development of atherosclerotic cardiovascular disease. It has become apparent that in …

Reduced levels of high-density lipoprotein cholesterol (HDL) are associated with a
substantially increased risk of coronary disease and cardiovascular events. Furthermore …

Plasma levels of high-density lipoprotein (HDL) are strongly and inversely correlated with
atherosclerotic cardiovascular diseases. However, it is becoming clear that a functional HDL …

Hypercholesterolemia is one of the main risk factors for the development of atherosclerosis.
Among the various lipoprotein classes, however, high density lipoproteins (HDL) are …

Accumulation of cholesterol by macrophages, leading to their transformation into foam cells
is a key event in the initiation of atherosclerosis. As maintenance of cholesterol homeostasis …

Plasma concentration of high density lipoprotein (HDL) is one of the most reliable negative
risk factors for CVD. There is however convincing experimental and clinical evidence that …

The inverse relationship between low plasma high-density lipoprotein cholesterol (HDL-C)
concentrations and increased risk of Atherosclerotic Cardiovascular Disease (ASCVD) is …