Study Design. A prospective, randomized laboratory investigation. Objective. To investigate
whether administration of minocycline attenuates hind-limb motor dysfunction and gray and …

OBJECTIVE: To investigate whether postischemic administration of minocycline attenuates
hind-limb motor dysfunction and gray and white matter injuries after spinal cord ischemia …

This study was initiated due to an NIH “Facilities of Research—Spinal Cord Injury” contract
to support independent replication of published studies that could be considered for a …

Preclinical studies have attributed neuroprotective properties to the antibiotic minocycline.
Animal studies and early clinical trials support its use in several neurological diseases. In …

Study design. A prospective, randomized experimental research. Objective. To evaluate the
short-and long-term neuroprotective effects of minocycline on the secondary injury process …

Minocycline (MC), a second-generation tetracycline and anti-inflammatory agent reportedly
provides neuroprotection following CNS injury. The objective of this study was to examine …

METHODS In this human pilot study, patients presenting within 12 hours of nonpenetrating
traumatic SCI were randomized in a double blind fashion to intravenous minocycline (200 …

Objective Minocycline, a second-generation tetracycline-class antibiotic, has been well
established to exert a neuroprotective effect in animal models and neurodegenerative …

Objectives Study explore the effects of minocycline on the expression of glial fibrillary acidic
protein and brain-derived neurotrophic factor after spinal cord injury and its possible …

We examined the effects of minocycline, an anti-inflammatory drug, on functional recovery
following spinal cord injury (SCI). Rats received a mild, weight-drop contusion injury to the …