Protein and peptide formulation development
S Ohtake, W Wang - Pharmaceutical Sciences Encyclopedia …, 2010 - Wiley Online Library
Proteins/peptides are generally much more sensitive to process‐or storage‐induced
degradations than small synthetic molecules. Therefore, significant efforts are needed to …
degradations than small synthetic molecules. Therefore, significant efforts are needed to …
Formulation and delivery of proteins and peptides: design and development strategies
JL Cleland, R Langer - 1994 - ACS Publications
The success of most peptide and protein drugs is dependent upon the delivery of the
biologically active form to the site of action. In the design and development of formulations to …
biologically active form to the site of action. In the design and development of formulations to …
A review on forced degradation strategies to establish the stability of therapeutic peptide formulations
Peptides are small polymers composed of 40 or fewer amino acids and are an increasingly
important class of drugs. Therapeutic peptides are less immunogenic and more economical …
important class of drugs. Therapeutic peptides are less immunogenic and more economical …
Strategies to Optimize Peptide Stability and Prolong Half-Life
SM Shi, L Di - … : Fundamentals of Design, Development, and Delivery, 2022 - Springer
Peptide drugs represent 5% of the global pharmaceutical market, but growing twice as fast
as the rest of the drug market. The development of peptide therapeutics is challenging due …
as the rest of the drug market. The development of peptide therapeutics is challenging due …
[PDF][PDF] Peptides and proteins as parenteral solutions
MJ Akers, MR Defelippis - … of peptides and proteins. London: Taylor …, 2000 - academia.edu
The purpose of this chapter is to provide practical guidance to formulation scientists charged
with the development of stable, manufacturable, and elegant solution dosage forms of …
with the development of stable, manufacturable, and elegant solution dosage forms of …
Modification of peptides and proteins
S Hostrup, K Huus, H Parshad - Delivery technologies for …, 2009 - Wiley Online Library
In the early drug development phases covering preformulation and formulation
development, the physicochemical properties of the protein drug are assessed. Efforts are …
development, the physicochemical properties of the protein drug are assessed. Efforts are …
Peptide stability in drug development: in vitro peptide degradation in plasma and serum
MF Powell - Annual Reports in Medicinal Chemistry, 1993 - Elsevier
Publisher Summary This chapter discusses chemical and physical stability of
pharmaceuticals, the effect of formulation stabilizers on peptide stability and protein/peptide …
pharmaceuticals, the effect of formulation stabilizers on peptide stability and protein/peptide …
Protein formulation and fill-finish operations
SY Patro, E Freund, BS Chang - 2002 - Elsevier
One of the challenges for the successful commercialization of therapeutic proteins is to
maintain the safety and efficacy of the protein during the manufacturing process, storage …
maintain the safety and efficacy of the protein during the manufacturing process, storage …
[引用][C] Stability of protein pharmaceuticals, part B: in vivo pathways of degradation and strategies for protein stabilization
TJ Ahern, MC Manning - 1992 - Springer
Part B explores protein degradation occuring in vivo during protein synthesis in cells,
examines the isolation and purification of proteins, details protein use in organisms, and …
examines the isolation and purification of proteins, details protein use in organisms, and …
Stabilization and delivery approaches for protein and peptide pharmaceuticals: an extensive review of patents
S Swain, D Mondal, S Beg… - Recent patents on …, 2013 - ingentaconnect.com
Proteins and peptides are the building blocks of human body and act as the arsenal to
combat against the invading pathogenic organisms for treatment and management of …
combat against the invading pathogenic organisms for treatment and management of …