The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands
work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the …

Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular
immune response comprising innate and adaptive phases. When the ocular immune system …

Ocular surface inflammation is propagated by a complex series of molecular processes and
has been implicated in the pathogenesis of dry eye disease (DED), either as a causal or a …

Most patients with chronic dry eye disease (DED) have episodic flares, which can be
triggered by a variety of activities and environmental stresses. These flares are typically …

Dry eye disease is a common and frequently occurring ophthalmology with complex and
diverse causes, and its incidence is on the upward trend. The pathogenesis of DED is still …

Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by
symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully …

Purpose: The purpose of this article is to review the evidence for the hypothesis that the core
mechanism of dry eye disease (DED) is inflammation, including evidence from recent basic …

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

Dry eye disease (DED) is a common, multifactorial ocular condition with major impact on
vision and quality of life. It is now well recognized that the pathophysiology of chronic DED …

Purpose: Dry eye disease (DED) is a prevalent inflammatory disorder of the lacrimal
functional unit of multifactorial origin leading to chronic ocular surface disease, impaired …