The advancements of civilization are based on our ability to pass on the events and
knowledge of the past so that the next generations can start from an ever-higher level of …

Cerebrospinal fluid (CSF) is a body fluid of choice for biomarker studies of brain disorders
but remains relatively under-studied compared with other biological fluids such as plasma …

Antimicrobial peptides (AMPs) are effector molecules that are able to kill or inactivate
microbial pathogens. However, most AMPs harbor multiple basic amino acids that hamper …

The role of a scientist is at first not so different from a philosopher. They both need to
question common thinking and evaluate whether reality is not as we always thought. Based …

Antimicrobial and immunomodulatory peptides (AMPs) are considered as the key players in
the maintenance of skin barrier functions. Here, we developed a novel approach for the …

A nano-HPLC-ESI-OrbiTrap study involving HCD and ETD spectra has been carried out to
clarify the composition of the skin peptidome of brown Russian frogs Rana temporaria. This …

BACKGROUND Technological advances have resulted in a renaissance of proteomic
studies directed at finding markers of disease progression, diagnosis, or responsiveness to …

Proteomics has evolved into an invaluable tool for biomedical research and for research on
renal diseases. A central player in the proteomic revolution is the mass spectrometer and its …

In current proteomic analysis, matrix-assisted laser desorption/ionization mass spectrometry
(MALDI-MS) is commonly used for protein identification. The MS-based protein identification …

We investigate the benefits and experimental feasibility of approaches enabling the shift
from short (1.7 kDa on average) peptides in bottom-up proteomics to about twice longer …