Blood-brain barrier (BBB) provides restrictions for the transportation of various therapeutic
agents to the brain. Efforts to directly target the brain by olfactory as well as trigeminal nerve …

Background Cranial nerve-related diseases such as brain tumors, Alzheimer's disease, and
epilepsy are serious diseases that continue to threaten human. Brain-related diseases are …

The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …

The treatment of brain disorders is the greatest challenge because of a variety of formidable
obstacles in effective drug delivery and maintaining therapeutic concentrations in the brain …

Many drugs are not being effectively and efficiently delivered using conventional drug
delivery approach to brain or central nervous system (CNS) due to its complexity. The brain …

Introduction: The blood–brain barrier (BBB) represents a stringent barrier for delivery of
neurotherapeutics in vivo. An attempt to overcome this barrier is represented by the direct …

The intricate pathophysiology of brain disorders, difficult access to the brain, and the
complexity and high risks and costs of drug development represent major hurdles for …

Background: The convoluted pathophysiology of brain disorders along with penetration
issue of drugs to brain represents major hurdle that requires some novel therapies. The …

The brain is the most delicate, complex, and vital organ of the human body, and is highly
protected by different protective structures including skull, meninges, cerebrospinal fluid …

Many of the therapeutics used for the treatment of brain disorders are not effective and not
delivered to the brain due to the complex structure and its barriers. In recent years, many …