Angiogenesis, or generation of new blood vessels from pre-existing vessels, is an integral
part of many physiological or pathological processes, including tumor growth. Physiological …

The angiogenic process involves several cell types and mediators, which interact to
establish a specific microenvironment suitable for the formation of new capillaries from pre …

Tumor angiogenesis is one of the hallmarks of tumor progression and is essential for
invasiveness and metastasis. Myeloid inflammatory cells, such as immature myeloid …

Here, we describe that microenvironmental IL-1β and, to a lesser extent, IL-1α are required
for in vivo angiogenesis and invasiveness of different tumor cells. In IL-1β knockout (KO) …

In this study, we assessed the involvement of IL-1β in early angiogenic responses induced
by malignant cells using Matrigel plugs supplemented with B16 melanoma cells. We found …

In recent years, pro‐oncogenic mechanisms of the tumour microenvironment (ТМЕ) have
been actively discussed. One of the main cytokines of the TМЕ is interleukin‐1 beta (IL‐1β) …

The immune system regulates angiogenesis in cancer with both pro-and antiangiogenic
activities. The induction of angiogenesis is mediated by tumor-associated macrophages and …

[Frontiers in Bioscience 10, 853-865, January 1, 2005] 853 THE ROLE OF INTERLEUKIN-8 IN
CANCER CELLS AND MICROENVIRONMENT INTERA Page 1 [Frontiers in Bioscience 10 …

The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory
responses both in response to and acting as danger signals. It has long been established …

Inflammatory conditions are associated with tumor development. IL-1β is a multifunctional
and proinflammatory cytokine that affects nearly all types of cells. To investigate the role of IL …