Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling
M Zheng, W Zhu, Q Han, RP Xiao - Pharmacology & therapeutics, 2005 - Elsevier
The stimulation of β-adrenergic receptor (βAR) plays a pivotal role in regulating myocardial
function and morphology in the normal and failing heart. Three genetically and …
function and morphology in the normal and failing heart. Three genetically and …
Blunted Cardiac Responses to Receptor Activation in Subjects With Thr164Ile β2-Adrenoceptors
OE Brodde, R Büscher, R Tellkamp, J Radke… - Circulation, 2001 - Am Heart Assoc
Background—Recent evidence indicates that certain genotypes of β2-adrenoceptors (AR)
may indicate an increased risk of cardiovascular disease or an increased rate of disease …
may indicate an increased risk of cardiovascular disease or an increased rate of disease …
The contribution of classical (β1/2-) and atypical β-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel …
MV Sennitt, AJ Kaumann, P Molenaar, LJ Beeley… - … of Pharmacology and …, 1998 - ASPET
The role of β3-and other putative atypical β-adrenoceptors in human white adipocytes and
right atrial appendage has been investigated using CGP 12177 and novel …
right atrial appendage has been investigated using CGP 12177 and novel …
The functional importance of beta1 and beta2 adrenoceptors in the human heart
OE Brodde - The American journal of cardiology, 1988 - Elsevier
Radioligand binding studies have demonstrated convincingly the coexistence of β 1 and β 2
adrenoceptors in the human heart. Both subtypes are involved in the increase in tissue …
adrenoceptors in the human heart. Both subtypes are involved in the increase in tissue …
Expression of three human β‐adrenergic‐receptor subtypes in transfected chinese hamster ovary cells
KM Tate, MM BRIEND‐SUTREN… - European journal of …, 1991 - Wiley Online Library
The genes coding for three pharmacologically distinct subtypes of human β‐adrenergic
receptors (β1AR, β2AR and β3AR) were transfected for expression in Chinese hamster …
receptors (β1AR, β2AR and β3AR) were transfected for expression in Chinese hamster …
The influence of diabetes on cardiac β-adrenoceptor subtypes
Despite the significant developments in the treatment of diabetes mellitus, diabetic patients
still continue to suffer from cardiac complications. The increase of cardiac adrenergic drive …
still continue to suffer from cardiac complications. The increase of cardiac adrenergic drive …
Cardiovascular and metabolic alterations in mice lacking both β1-and β2-adrenergic receptors
DK Rohrer, A Chruscinski, EH Schauble… - Journal of Biological …, 1999 - ASBMB
The activation state of β-adrenergic receptors (β-ARs) in vivo is an important determinant of
hemodynamic status, cardiac performance, and metabolic rate. In order to achieve …
hemodynamic status, cardiac performance, and metabolic rate. In order to achieve …
A gain-of-function polymorphism in a G-protein coupling domain of the human β1-adrenergic receptor
DA Mason, JD Moore, SA Green, SB Liggett - Journal of Biological …, 1999 - ASBMB
The β 1-adrenergic receptor (β 1 AR) is a key cell surface signaling protein expressed in the
heart and other organs that mediates the actions of catecholamines of the sympathetic …
heart and other organs that mediates the actions of catecholamines of the sympathetic …
Regional Distribution of β-Adrenoceptors in the Human Heart: Coexistence of Functional β: 1: and β: 2:-Adrenoceptors in Both Atria and Ventricles in Severe …
OE Brodde, S Schüler, R Kretsch… - Journal of …, 1986 - journals.lww.com
We evaluated the amount of [beta] 1-and [beta] 2-adrenoceptors in human right and left
atrium as well as in right and left ventricular wall obtained from heart transplant recipients …
atrium as well as in right and left ventricular wall obtained from heart transplant recipients …
The effects of newer beta-adrenoceptor antagonists on vascular function in cardiovascular disease
M Wehland, J Grosse, U Simonsen… - Current vascular …, 2012 - ingentaconnect.com
This review provides a systematic overview of the influence of the third generation beta-
adrenoceptor antagonists on vascular and/or endothelial function at a cellular level as well …
adrenoceptor antagonists on vascular and/or endothelial function at a cellular level as well …