Publisher Summary This chapter discusses the osteoblast lineage. The advent of cell culture
and molecular biology has seen an explosion in information on the osteoblast lineage, bone …

Osteoblasts are the skeletal cells responsible for synthesis, deposition, and mineralization of
the extracellular matrix of bone. By mechanisms that are only beginning to be understood …

This paper addresses some of the important aspects of stem cell commitment to the bone
cell lineage examining the various types of precursor cells, their responses to cytokines and …

Publisher Summary This chapter focuses on osteoblast biology and bone formation. Bone
formation may be classicaIly defined as the process by which osteoblasts synthesize and …

Osteoblasts are derived from a variety of progenitor populations, including bone marrow,
neural crest, and periosteal cells. Osteoblasts produce extracellular matrix proteins and …

Bone formation takes place in the organism during embryonic development, growth,
remodeling, fracture repair and when induced experimentally, eg, by the implantation of …

The inherent heterogeneity of bone cells complicates the interpretation of microarray studies
designed to identify genes highly associated with osteoblast differentiation. To overcome …

Bone is a complex tissue that contains at least four different cell types of the osteoblastic
lineage.(1) Active osteoblast-a plump, polarized, cuboidal cell rich in organelles involved in …

Bone development and the adaptation of the adult skeleton to mechanical needs and
hormonal changes depend on the ability of bone cells to resorb and form bone in the right …

Publisher Summary This chapter provides an overview of the osteoblast lineage and
discusses the possibilities for recognizing stages of differentiation or maturity. Bone …