Heparin is the earliest and most widely used anticoagulant and antithrombotic drug that is
still used in a variety of clinical indications. Since it was discovered in 1916, after more than …

Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100
years have passed since the initial discovery of this complex substance and, during this …

Heparin is a life-saving drug, which belongs to few clinically used drugs without defined
molecular structures in modern medicine. Heparin is the mostly negatively charged …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Heparin, an old but first-line anticoagulant, has been used over a century. It is a
heterogeneous, linear, highly sulfated, anionic glycosaminoglycan with a broad distribution …

Heparins represent one of the most frequently used pharmacotherapeutics. Discovered
around 1926, routine clinical anticoagulant use of heparin was initiated only after the …

Heparin has been widely used as an anticoagulant for more than 80 years. However, there
is now considerable evidence that heparin also possesses anti‐inflammatory activity, both …

The history of heparin is described from its initial discovery in 1916 to recent developments
in knowledge of its mechanism of action and clinical use. Commercial production started …

A number of physiological effects have been ascribed to heparin since its discovery almost
80 years ago, many of which are independent from its first-described and best-characterized …

2. Dianne K, Jennings I, Kitchen S, Walker I. Letter in response to article “Systematic review
of viscoelastic testing (TEG/Rotem) in obstetrics and recommendations from the women's …