Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm
B Wang, Z Li, C Wang, M Chen, J Xiao, X Wu, W Xiao… - PloS one, 2013 - journals.plos.org
Human sperm cryopreservation for assisted reproduction is compromised by ROS-induced
sperm cryodamage. Our previous model study in which mouse sperm were treated with …
sperm cryodamage. Our previous model study in which mouse sperm were treated with …
Phospho-Cdc25 correlates with activating G2/M checkpoint in mouse zygotes fertilized with hydrogen peroxide-treated mouse sperm
Y Song, Z Li, B Wang, J Xiao, X Wang… - Molecular and cellular …, 2014 - Springer
The presence of oxidative stress in sperm cryopreservation induces sperm DNA damage.
Our previous study has discovered that γH2AX, the DNA-damaged marker, was activated in …
Our previous study has discovered that γH2AX, the DNA-damaged marker, was activated in …
Effects of the insemination of hydrogen peroxide-treated epididymal mouse spermatozoa on γH2AX repair and embryo development
J Xiao, Y Liu, Z Li, Y Zhou, H Lin, X Wu, M Chen… - PLoS …, 2012 - journals.plos.org
Background Cryopreservation of human semen for assisted reproduction is complicated by
cryodamage to spermatozoa caused by excessive reactive oxygen species (ROS) …
cryodamage to spermatozoa caused by excessive reactive oxygen species (ROS) …
[HTML][HTML] Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2
Y Zhang, D Qian, Z Li, Y Huang, Q Wu, G Ru… - Cell Stress and …, 2016 - Elsevier
In vitro fertilized (IVF) embryos show both cell cycle and developmental arrest. We
previously showed oxidative damage activates the ATM→ Chk1→ Cdc25B/Cdc25C …
previously showed oxidative damage activates the ATM→ Chk1→ Cdc25B/Cdc25C …
ROS-induced oxidative stress is a major contributor to sperm cryoinjury
H Shi, QY Li, H Li, HY Wang, CX Fan… - Human …, 2024 - academic.oup.com
STUDY QUESTION What is the mechanism behind cryoinjury in human sperm, particularly
concerning the interplay between reactive oxygen species (ROS) and autophagy, and how …
concerning the interplay between reactive oxygen species (ROS) and autophagy, and how …
Effect of epigallocatechin-3-gallate (EGCG) on embryos inseminated with oxidative stress-induced DNA damage sperm
M Chen, W Liu, Z Li, W Xiao - Systems Biology in Reproductive …, 2020 - Taylor & Francis
Cryopreservation can induce damage in human spermatozoa through reactive oxygen
species (ROS) generation. To reduce the potential risk of oxidative stress-induced sperm …
species (ROS) generation. To reduce the potential risk of oxidative stress-induced sperm …
[HTML][HTML] Ability of deoxyribonucleic acid–damaged sperm to withstand freeze-thaw–induced damage during cryopreservation
OBJECTIVE: To understand the association between sperm DNA damage and the ability of
DNA-damaged sperm to withstand the freeze-thaw process during cryopreservation …
DNA-damaged sperm to withstand the freeze-thaw process during cryopreservation …
Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis
LK Thomson, SD Fleming, RJ Aitken… - Human …, 2009 - academic.oup.com
BACKGROUND Whereas studies have revealed that the cryopreservation of human semen
increases sperm DNA fragmentation, the mechanisms involved in this type of cryo-injury are …
increases sperm DNA fragmentation, the mechanisms involved in this type of cryo-injury are …
Impact of cryopreservation and reactive oxygen species on DNA integrity, lipid peroxidation, and functional parameters in ram sperm
SI Peris, JF Bilodeau, M Dufour… - Molecular reproduction …, 2007 - Wiley Online Library
Assisted reproduction using frozen‐thawed semen has practical advantages, although
cryopreservation is detrimental to sperm fertility in most mammals. We examined the …
cryopreservation is detrimental to sperm fertility in most mammals. We examined the …
Mitochondrial hydrogen peroxide and defective cholesterol efflux prevent in vitro fertilization by cryopreserved inbred mouse sperm
Recent advances in the cryopreservation of mouse sperm have resulted in dramatically
improved in vitro fertilization (IVF) rates, but the biological mechanisms underlying the …
improved in vitro fertilization (IVF) rates, but the biological mechanisms underlying the …