Long noncoding RNAs in cancer and therapeutic potential

A Renganathan, E Felley-Bosco - Long Non Coding RNA Biology, 2017 - Springer
Long noncoding RNAs (lncRNAs) are the major elements of the mammalian transcriptome
that is emerging as a central player controlling diverse cellular mechanisms. Most of the well …

[HTML][HTML] Exploring the mechanisms behind long noncoding RNAs and cancer

MM Balas, AM Johnson - Non-coding RNA research, 2018 - Elsevier
Over the past decade, long noncoding RNAs (lncRNAs) have been identified as significant
players in gene regulation. They are often differentially expressed and widely-associated …

[HTML][HTML] Long noncoding RNAs and their link to cancer

JM Grixti, D Ayers - Non-coding RNA research, 2020 - Elsevier
The central dogma of molecular biology, developed from the study of simple organisms such
as Escherichia coli, has up until recently been that RNA functions mainly as an information …

Long noncoding RNAs in cancer: from discovery to therapeutic targets

R Choudhari, MJ Sedano, AL Harrison… - Advances in clinical …, 2020 - Elsevier
Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key
players in biological regulation; however, the mechanisms by which lncRNAs govern …

Long noncoding RNAs in cancer: mechanisms of action and technological advancements

N Bartonicek, JLV Maag, ME Dinger - Molecular cancer, 2016 - Springer
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …

Long non-coding RNA in the pathogenesis of cancers

Y Chi, D Wang, J Wang, W Yu, J Yang - Cells, 2019 - mdpi.com
The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Perspectives of long non-coding RNAs in cancer

AKDM Rao, T Rajkumar, S Mani - Molecular biology reports, 2017 - Springer
A recent advance in transcriptomics has spawned the 'Decade of non-coding RNAs' by
potentiating the growing numbers of long non-coding RNA in cancer. LncRNA involvement …

Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers

N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Long noncoding RNAs in cancer cells

DH Bach, SK Lee - Cancer letters, 2018 - Elsevier
Long noncoding RNA (lncRNA) has recently been investigated as key modulators that
regulate many biological processes in human cancers via diverse mechanisms. LncRNAs …

Emerging roles of long non‐coding RNA in cancer

A Sanchez Calle, Y Kawamura, Y Yamamoto… - Cancer …, 2018 - Wiley Online Library
Since comprehensive analysis of the mammalian genome revealed that the majority of
genomic products are transcribed in long non‐coding RNA (lnc RNA), increasing attention …