Genome-wide translating mRNA analysis following ketamine reveals novel targets for antidepressant treatment
Low-dose ketamine is an efficacious antidepressant for treatment-resistant unipolar and
bipolar depressed patients. Major Depression Disorder patients receiving a single infusion …
bipolar depressed patients. Major Depression Disorder patients receiving a single infusion …
Ketamine's pharmacogenomic network in human brain contains sub-networks associated with glutamate neurotransmission and with neuroplasticity
GA Higgins, SA Handelman, A Allyn-Feuer, AS Ade… - bioRxiv, 2020 - biorxiv.org
The pharmacogenomic network responsible for the rapid antidepressant action of ketamine
and concomitant adverse events in patients has been poorly defined. Integrative, multi-scale …
and concomitant adverse events in patients has been poorly defined. Integrative, multi-scale …
W37. CHANGES IN PERIPHERAL GENE EXPRESSION FOLLOWING ANTIDEPRESSANT KETAMINE TREATMENT
A Zavaliangos-Petropulu, T Boltz, N Al-Sharif… - European …, 2023 - Elsevier
Background Sub-anesthetic ketamine prompts rapid and robust antidepressant response in
60-70% of patients with treatment resistant depression (TRD), however the underlying …
60-70% of patients with treatment resistant depression (TRD), however the underlying …
Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action
Background The NMDA receptor antagonist ketamine was found to act as a fast-acting
antidepressant. The effects of single treatment were reported to persist for days to weeks …
antidepressant. The effects of single treatment were reported to persist for days to weeks …
[HTML][HTML] The mechanisms behind rapid antidepressant effects of ketamine: a systematic review with a focus on molecular neuroplasticity
The mechanism of action underlying ketamine's rapid antidepressant effects in patients with
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD) …
[PDF][PDF] Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons
A Kawatake-Kuno, H Li, H Inaba, M Hikosaka… - Neuron, 2024 - cell.com
Despite the rapid and sustained antidepressant effects of ketamine and its metabolites, their
underlying cellular and molecular mechanisms are not fully understood. Here, we …
underlying cellular and molecular mechanisms are not fully understood. Here, we …
Molecular Mechanism and Clinical Relevance of Ketamine as Rapid‐Acting Antidepressant
V Pešić, J Petrović, MM Jukić - Drug development research, 2016 - Wiley Online Library
ABSTRACT Preclinical Research The emergence of rapid‐acting antidepressants such as
ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine …
ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine …
Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine
Subanesthetic ketamine evokes rapid antidepressant effects in human patients that persist
long past ketamine's chemical half-life of~ 2 h. Ketamine's sustained antidepressant action …
long past ketamine's chemical half-life of~ 2 h. Ketamine's sustained antidepressant action …
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
TH Pham, AM Gardier - Pharmacology & therapeutics, 2019 - Elsevier
Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …
a fast antidepressant activity in treatment-resistant depression and in rodent models of …