Background & Objective: Ketamine, a noncompetitive NMDA receptor antagonist, exhibits
rapid antidepressant actions, but the underlying mechanism remains obscure. AMPA …

In this pilot study (N= 9), we highlight new insights gained on ketamine's mechanism of
action where we have mapped biochemical processes that are affected within 40 min of …

Delayed onset of antidepressant action is a shortcoming in depression treatment. Ketamine
and its metabolite (2R, 6R)-hydroxynorketamine (HNK) have emerged as promising rapid …

Ketamine has been found to have rapid, long-lasting antidepressant effects in treatment-
resistant (TR) patients with major depressive disorder (MDD). Recently, we have also shown …

Ketamine is a multifunctional drug with clinical applications as an anesthetic, pain
management medication, and a fast-acting antidepressant. However, it is also recreationally …

(R, S)-ketamine (ketamine) has rapid and sustained antidepressant (AD) efficacy at sub-
anesthetic doses in depressed patients. A metabolite of ketamine, including (2R, 6R) …

Over the last decade, numerous controlled studies have consistently described rapid, robust,
and relatively sustained antidepressant response rates associated with single-dose …

Major depressive disorder is a highly prevalent psychiatric disorder. Despite an extensive
range of treatment options, about a third of patients still struggle to respond to available …

Approximately two-thirds of patients with major depressive disorder (MDD) fail to respond to
conventional antidepressants, suggesting that additional mechanisms are involved in the …

Administration of multiple subanesthetic doses of ketamine increases the duration of
antidepressant effects relative to a single ketamine dose, but the mechanisms mediating this …