Microglia-mediated neuroinflammation is involved in various neurological diseases,
including ischemic stroke, but the endogenous mechanisms preventing unstrained …

Stroke is reported as a leading cause of mortality and disability in the world.
Neuroinflammation is significantly induced responding to ischemic stroke, and this process …

Microglia cells fulfill key homeostatic functions and essentially contribute to host defense
within the CNS. Altered activation of microglia, in turn, has been implicated in …

Abstract Aims Adenosine 2A receptor (A2AR) is widely expressed in the brain and plays
important roles in neuroinflammation, and the nucleotide‐binding oligomerization domain …

Microglia are resident macrophages in the central nervous system (CNS) that play a major
role in neuroinflammation and pathogenesis of several neurodegenerative diseases. Upon …

Growing evidences suggest that sustained neuroinflammation, caused by microglia
overactivation, is implicated in the development and aggravation of several neurological and …

Fine regulation of the innate immune response following brain injury or infection is important
to avoid excessive activation of microglia and its detrimental consequences on neural cell …

Microglia are activated following cerebral ischemia and increase their production of the
neuro-and immunomodulatory cytokine tumor necrosis factor (TNF). To address the function …

Ischemic stroke refers to the sudden loss of blood flow in a specific area of the brain. It is the
fifth leading cause of mortality and the leading cause of permanent disability. The …

Purpose MicroRNAs (miRNAs) are emerging as essential regulators in the development of
cerebral ischemia/reperfusion (I/R) injury. This study aimed to explore the regulation of miR …