Ionic liquids for enhanced drug delivery: recent progress and prevailing challenges

C Liu, B Chen, W Shi, W Huang… - Molecular Pharmaceutics, 2022 - ACS Publications
Ionic liquids (ILs) are a class of nonmolecular compounds composed only of ions.
Compared with traditional organic solvents, ILs have the advantages of wide chemical …

Ionic liquids as a potential tool for drug delivery systems

N Adawiyah, M Moniruzzaman, S Hawatulaila… - …, 2016 - pubs.rsc.org
The pharmaceutical industries face a series of challenges in the delivery of many newly
developed drug molecules because of their low solubility, bioavailability, stability and …

Impact of ionic liquids in environment and humans: an overview

RFM Frade, CAM Afonso - Human & experimental toxicology, 2010 - journals.sagepub.com
Ionic liquids enclose a large number of molecular structures consisting of a cation and an
anion. Their physical state and their chemical properties can be tuned by different …

Ionic liquids in biotechnology and beyond

J Claus, FO Sommer, U Kragl - Solid State Ionics, 2018 - Elsevier
In the past decades, ionic liquids (IL) evolved from a “designer solvent” to a well-known and
well-characterized class of compounds useful in reactions, extractions, and other …

Use of ionic liquids in protein and DNA chemistry

SK Shukla, JP Mikkola - Frontiers in Chemistry, 2020 - frontiersin.org
Ionic liquids (ILs) have been receiving much attention as solvents in various areas of
biochemistry because of their various beneficial properties over the volatile solvents and ILs …

Ionic liquids for addressing unmet needs in healthcare

C Agatemor, KN Ibsen, EEL Tanner… - Bioengineering & …, 2018 - Wiley Online Library
Advances in the field of ionic liquids have opened new applications beyond their traditional
use as solvents into other fields especially healthcare. The broad chemical space, rich with …

Industrial application of ionic liquids as performance additives

B Weyershausen, K Lehmann - Green Chemistry, 2005 - pubs.rsc.org
Over the last decade ionic liquids have achieved much attention and are not any longer just
a class of esoteric compounds, but are proving to be valuable and useful in a multitude of …

Ionic liquids in heterocyclic synthesis

MAP Martins, CP Frizzo, DN Moreira, N Zanatta… - Chemical …, 2008 - ACS Publications
Heterocycles form by far the largest of the classical divisions of organic chemistry. Moreover,
they are of immense importance not only both biologically and industrially but to the …

An unexpected increase of toxicity of amino acid-containing ionic liquids

KS Egorova, MM Seitkalieva… - Toxicology …, 2015 - academic.oup.com
Functionalization of ionic liquids (ILs) with natural amino acids is usually considered as a
convenient approach to decrease their toxicity and find new areas of chemical application as …

Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids

V Kumar, SV Malhotra - Bioorganic & medicinal chemistry letters, 2009 - Elsevier
The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids
(ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The …