The interaction between pathogenic microorganisms and their hosts is regulated by
reciprocal survival strategies, including competition for essential nutrients. Though …

Enhanced amino acid catabolism is a common response to inflammation, but the
immunologic significance of altered amino acid consumption remains unclear. The finding …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

The interaction between host and pathogen decidedly shapes the outcome of an infection,
thus understanding this interaction is critical to the treatment of a pathogen-induced …

Immune-cell activation and functional plasticity are closely linked to metabolic
reprogramming that is required to supply the energy and substrates for such dynamic …

Intracellular bacterial pathogens often rely on their hosts for essential nutrients. Host cells, in
turn, attempt to limit nutrient availability, using starvation as a mechanism of innate immunity …

Defences to pathogens such as SarCoV2 in mammals involves interactions between
immune functions and metabolic pathways to eradicate infection while preventing …

Autophagy, which targets cellular constituents for degradation, is normally inhibited in
metabolically replete cells by the metabolic checkpoint kinase mTOR. Although autophagic …

Dietary amino acids (AAs) are not only absorbed and metabolized by enterocytes but also
available to the microbiota in the gut in mammals. In addition to serving as the materials for …

Abstract Indoleamine 2, 3-dioxygenases (IDOs)− belonging in the heme dioxygenase family
and degrading tryptophan− are responsible for the de novo synthesis of nicotinamide …