The interaction between pathogenic microorganisms and their hosts is regulated by
reciprocal survival strategies, including competition for essential nutrients. Though …

Enhanced amino acid catabolism is a common response to inflammation, but the
immunologic significance of altered amino acid consumption remains unclear. The finding …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

The interaction between host and pathogen decidedly shapes the outcome of an infection,
thus understanding this interaction is critical to the treatment of a pathogen-induced …

Immune-cell activation and functional plasticity are closely linked to metabolic
reprogramming that is required to supply the energy and substrates for such dynamic …

Intracellular bacterial pathogens often rely on their hosts for essential nutrients. Host cells, in
turn, attempt to limit nutrient availability, using starvation as a mechanism of innate immunity …

Defences to pathogens such as SarCoV2 in mammals involves interactions between
immune functions and metabolic pathways to eradicate infection while preventing …

Autophagy, which targets cellular constituents for degradation, is normally inhibited in
metabolically replete cells by the metabolic checkpoint kinase mTOR. Although autophagic …

Arginine is a crucial amino acid that serves to modulate the cellular immune response
during infection. Arginine is also a common substrate for both inducible nitric oxide synthase …

Abstract Indoleamine 2, 3-dioxygenases (IDOs)− belonging in the heme dioxygenase family
and degrading tryptophan− are responsible for the de novo synthesis of nicotinamide …