Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures

S Xapelli, F Agasse, L Sardà-Arroyo, L Bernardino… - PloS one, 2013 - journals.plos.org
The endocannabinoid system has been implicated in the modulation of adult neurogenesis.
Here, we describe the effect of type 1 cannabinoid receptor (CB1R) activation on self …

Interaction between cannabinoid type 1 and type 2 receptors in the modulation of subventricular zone and dentate gyrus neurogenesis

RS Rodrigues, FF Ribeiro, F Ferreira, SH Vaz… - Frontiers in …, 2017 - frontiersin.org
Neurogenesis in the adult mammalian brain occurs mainly in two neurogenic niches, the
subventricular zone (SVZ) and the subgranular zone (SGZ) of the dentate gyrus (DG) …

Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice

K Jin, L Xie, SH Kim, S Parmentier-Batteur, Y Sun… - Molecular …, 2004 - ASPET
Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating
neurogenesis in the adult brain. To investigate this possibility, we measured neurogenesis …

CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling

S Trazzi, M Steger, VM Mitrugno, R Bartesaghi… - Journal of Biological …, 2010 - ASBMB
The endocannabinoid system is involved in the regulation of many physiological effects in
the central and peripheral nervous system. Recent findings have demonstrated the …

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors

J Paraíso-Luna, J Aguareles, R Martín… - …, 2020 - journals.biologists.com
The endocannabinoid (eCB) system, via the cannabinoid CB1 receptor, regulates
neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB1 …

Brain-derived neurotrophic factor (BDNF) role in cannabinoid-mediated neurogenesis

FF Ferreira, FF Ribeiro, RS Rodrigues… - Frontiers in cellular …, 2018 - frontiersin.org
The adult mammalian brain can produce new neurons in a process called adult
neurogenesis, which occurs mainly in the subventricular zone (SVZ) and in the hippocampal …

Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells

C Compagnucci, S Di Siena, MB Bustamante… - PloS one, 2013 - journals.plos.org
Neural stem cells (NSCs) are self-renewing cells that can differentiate into multiple neural
lineages and repopulate regions of the brain after injury. We have investigated the role of …

CB2 cannabinoid receptors promote mouse neural stem cell proliferation

F Molina‐Holgado, A Rubio‐Araiz… - European Journal of …, 2007 - Wiley Online Library
Neurospheres are clonal cellular aggregates of neural stem/precursor cells that grow in
culture as free‐floating clusters. Activation of CB1 cannabinoid receptors, which are …

Role for neuronal nitric-oxide synthase in cannabinoid-induced neurogenesis

SH Kim, SJ Won, XO Mao, C Ledent, K Jin… - … of Pharmacology and …, 2006 - ASPET
Cannabinoids, acting through the CB1 cannabinoid receptor (CB1R), protect the brain
against ischemia and related forms of injury. This may involve inhibiting the neurotoxicity of …

Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus

T Zimmermann, M Maroso, A Beer… - Cerebral …, 2018 - academic.oup.com
Neural stem cells (NSCs) in the adult mouse hippocampus occur in a specific neurogenic
niche, where a multitude of extracellular signaling molecules converges to regulate NSC …