Cellular functions of proteins are strongly influenced by their interactions with other proteins.
The frequency of protein interactions is a function of the local concentration of two proteins …

A growing number of protein interactions are found to be mediated by a large globular
region in one protein binding to a comparatively short, peptide stretch in another. Regions …

An important goal in protein engineering is to control associations between designed
proteins. This is most often done by fusing known, naturally occurring oligomerization …

Protein-protein recognition usually involves multiple interactions among different motifs that
are scattered over protein surfaces. To identify such weak interactions, we have developed a …

The eukaryotic signaling protein calmodulin (CaM) can bind to more than 300 known target
proteins to regulate numerous functions in our body in a calcium-dependent manner. How …

It is becoming increasingly clear that eukaryotic cell physiology is largely controlled by
protein–protein interactions involving disordered protein regions, which usually interact with …

The dynamic formation of selective protein-protein interactions is an essential part of the
cellular signal transduction cascades. although these interactions have a great potential for …

Information transfer from activated heterotrimeric guanine nucleotide-binding proteins (G
proteins) to downstream effectors occurs through noncovalent protein-protein interactions …

A substantial fraction of protein interactions in the cell is mediated by families of protein
modules binding to relatively short linear peptides. Many of these interactions have a high …

We describe a rapid and efficient in vivo library-versus-library screening strategy for
identifying optimally interacting pairs of heterodimerizing polypeptides. Two leucine zipper …