Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives
Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers
J Fang, W Islam, H Maeda - Advanced drug delivery reviews, 2020 - Elsevier
The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid
tumors that is related to their particular anatomical and pathophysiological characteristics …
tumors that is related to their particular anatomical and pathophysiological characteristics …
EPR: Evidence and fallacy
JW Nichols, YH Bae - Journal of Controlled Release, 2014 - Elsevier
The enhanced permeability and retention (EPR) of nanoparticles in tumors has long stood
as one of the fundamental principles of cancer drug delivery, holding the promise of safe …
as one of the fundamental principles of cancer drug delivery, holding the promise of safe …
[HTML][HTML] Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?
H Kobayashi, R Watanabe, PL Choyke - Theranostics, 2014 - ncbi.nlm.nih.gov
Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …
such as a larger loading capacity, the ability to protect the payload until delivery, more …
Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?
F Danhier - Journal of Controlled Release, 2016 - Elsevier
Tumor targeting by nanomedicine-based therapeutics has emerged as a promising
approach to overcome the lack of specificity of conventional chemotherapeutic agents and to …
approach to overcome the lack of specificity of conventional chemotherapeutic agents and to …
Tumor delivery of macromolecular drugs based on the EPR effect
V Torchilin - Advanced drug delivery reviews, 2011 - Elsevier
Enhanced permeability and retention (EPR) effect is the physiology-based principal
mechanism of tumor accumulation of large molecules and small particles. This specific issue …
mechanism of tumor accumulation of large molecules and small particles. This specific issue …
Enhanced permeability and retention effect for selective targeting of anticancer nanomedicine: are we there yet?
K Greish - Drug Discovery Today: Technologies, 2012 - Elsevier
Enhanced permeability and retention (EPR) effect is a popular strategy for targeting
nanosize anticancer drugs to tumor tissues. In this review we discuss how EPR effect …
nanosize anticancer drugs to tumor tissues. In this review we discuss how EPR effect …
Tumor targeting via EPR: Strategies to enhance patient responses
The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …