Background Hereditary angio-oedema is a recurrent, oedematous disorder caused by
deficiency of functional C1 inhibitor. Infusions of plasma-derived C1 esterase inhibitor deter …

Background Hereditary angioedema (HAE) is a debilitating disorder resulting from C1-
esterase inhibitor (C1-INH) deficiency. In the COMPACT phase 3 study the prophylactic use …

Background Hereditary angioedema (HAE), caused by C1 inhibitor (C1INH) deficiency or
dysfunction, is characterized by recurrent attacks of tissue swelling affecting multiple …

To cite this article: Craig TJ, Bewtra AK, Bahna SL, Hurewitz D, Schneider LC, Levy RJ, Moy
JN, Offenberger J, Jacobson KW, Yang WH, Eidelman F, Janss G, Packer FR, Rojavin MA …

Human plasma-derived C1-esterase inhibitor (C1–INH) is an efficacious and safe treatment
for hereditary angioedema. However, thrombotic events in subjects treated with C1–INH at …

Limited data are available on recombinant human C1 esterase inhibitor as short-term
prophylaxis. A case series of 51 patients (70 procedures) indicated that recombinant human …

In the vast majority of patients with hereditary angioedema (HAE), angioedema attacks are
due to the quantitative or functional deficiency of C1-esterase inhibitor (C1-INH), which …

Background Symptoms of hereditary angioedema (HAE) attacks can recur soon after initial
treatment; the durability of response for recombinant human C1 esterase inhibitor (rhC1INH) …

Background Hereditary angioedema is a disabling, potentially fatal condition caused by
deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use …

Background The plasma-derived, pasteurized C1-inhibitor (C1-INH) concentrate, Berinert
has a 4-decade history of use in hereditary angioedema (HAE), with a substantial literature …