The urokinase plasminogen activator system is a family of serine proteases which consists
of uPA (urokinase plasminogen activator), uPAR (urokinase type plasminogen activator …

Introduction: The urokinase plasminogen activator (uPA) system, comprising the serine
protease uPA, its cognate receptor, uPAR, and two endogenous inhibitors, plasminogen …

Urokinase plasminogen activator (uPA) system regulates extracellular matrix remodelling by
activating ubiquitous protease plasmin in many important physiological processes. The …

Currently, there are several studies supporting the role of urokinase‐type plasminogen
activator (uPA) system in cancer. The association of uPA to its receptor triggers the …

Recent advancements in cancer research have led to some major breakthroughs; however,
the impact on overall cancer-related death rate remains unacceptable, suggesting that …

Background: Urokinase type plasminogen activator (uPA) is a 53-kDa serine protease
initially synthesized as a catalytically inactive single chain polypeptide. Inactive-uPA is …

The urokinase plasminogen activator (uPA) system is an endogenous proteolytic cascade
which can be actively subverted by the neoplastic process to facilitate progression and …

The plasminogen activator (PA) system is an extracellular proteolytic enzyme system
associated with various physiological and pathophysiological processes. A large body of …

Importance of the field: The serine protease urokinase-type plasminogen activator (uPA) and
its receptor uPAR as well as two specific inhibitors, the plasminogen activator inhibitor type …

Malignant tumors have a capacity to degrade the extracellular matrix (ECM) by controlled
proteolysis. One proteolytic system involved in these processes is the urokinase-type …