Paracoccidioides brasiliensis causes infection through host inhalation of airborne
propagules of the mycelial phase of the fungus, which reach the lungs, and then …

Parasites belonging to the Apicomplexa phylum are among the most successful pathogens
known in nature. They can infect a wide range of hosts, often remain undetected by the …

The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3
(Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14 …

The threat burden from pathogenic fungi is universal and increasing with alarming high
mortality and morbidity rates from invasive fungal infections. Understanding the virulence …

Members of the Paracoccidioides complex are human pathogens that infect different
anatomic sites in the host. The ability of Paracoccidioides spp. to infect host niches is …

Studying host-pathogen interaction enables us to understand the underlying mechanisms of
the pathogenicity during microbial infection. The prognosis of the host depends on the …

Background Paracoccidioidomycosis (PCM), an endemic systemic mycosis caused by the
fungus Paracoccidioides brasiliensis (Pb), usually results in severe lung damage in patients …

The emerging resistance of human-pathogenic fungi to antifungal drugs urges the
development of alternative therapeutic strategies. The small, cationic antifungal proteins …

Fungal infections are increasing due to the growing number of immunocompromised
patients. Because in vitro antifungal testing has limitations, animal models remain the …

Elucidation of pathogenicity mechanisms of the most important human-pathogenic fungi,
Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the …