Nuclear factor erythroid 2-related factor 2 (Nrf2) is over-expressed in many types of tumor,
promotes tumor growth, and confers resistance to anticancer therapy. Hence, Nrf2 is …

Targeted therapy based on natural compounds is one of the best approaches against non-
small cell lung cancer. Ursolic acid (UA), a pentacyclic triterpenoid derived from medicinal …

Lung adenocarcinoma (LUAD) is a common type of lung cancer with high frequent
metastasis and a high death rate. However, genes responsible for LUAD metastasis are still …

Chromium exists mostly in two valence states in nature: hexavalent chromium [chromium
(VI)] and trivalent chromium [chromium (III)]. Chromium (VI) is commonly used in industrial …

Targeting tumor necrosis factor (TNF)-α-mediated signal pathways may be a promising
strategy for developing chemopreventive agents, because TNF-α-mediated cyclooxygenase …

Ten years have elapsed since the International Agency for Research on Cancer (IARC)
evaluated the carcinogenicity of chromium and chromium compounds. Further studies …

Cr (VI) compounds are known human carcinogens that primarily target the lungs. Cr (VI)
produces reactive oxygen species (ROS), but the exact effects of ROS on the signaling …

Luteolin has been shown to exhibit anti-cancer activity against several forms of cancers,
including human hepatic cancers. Many in vitro studies have reported anti-oxidant effects of …

Luteolin is a natural flavonoid with strong anti–oxidative properties that is reported to have
an anti–cancer effect in several malignancies other than bladder cancer. In this study, we …

Nuclear erythroid-related factor 2 (Nrf2), a redox-sensitive transcription factor, is involved in
transcriptional regulation of many antioxidant genes, including glutamate-cysteine ligase …