Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices

T Hickey, D Kreutzer, DJ Burgess, F Moussy - Biomaterials, 2002 - Elsevier
The purpose of this research was to develop polylactic-co-glycolic acid (PLGA)
microspheres for continuous delivery of dexamethasone for over a 1-month period, in an …

In vivo evaluation of a dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices

T Hickey, D Kreutzer, DJ Burgess… - Journal of Biomedical …, 2002 - Wiley Online Library
The purpose of this research effort was to evaluate in vivo a newly developed
dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue …

PLGA/PVA hydrogel composites for long-term inflammation control following sc implantation

U Bhardwaj, R Sura, F Papadimitrakopoulos… - International journal of …, 2010 - Elsevier
Dexamethasone loaded PLGA microsphere/PVA hydrogel composites were investigated as
an outer drug-eluting coating for implantable devices to provide protection against the …

Controlling acute inflammation with fast releasing dexamethasone-PLGA microsphere/PVA hydrogel composites for implantable devices

U Bhardwaj, R Sura… - Journal of diabetes …, 2007 - journals.sagepub.com
Background: Continuous release of dexamethasone from PLGA microsphere/PVA hydrogel
composites has been shown to suppress the inflammatory tissue reaction in response to …

Accelerated in vitro release testing of implantable PLGA microsphere/PVA hydrogel composite coatings

J Shen, DJ Burgess - International journal of pharmaceutics, 2012 - Elsevier
Dexamethasone loaded poly (lactic-co-glycolic acid)(PLGA) microsphere/PVA hydrogel
composites have been investigated as an outer drug-eluting coating for implantable devices …

Dexamethasone-loaded poly (lactic-co-glycolic) acid microspheres/poly (vinyl alcohol) hydrogel composite coatings for inflammation control

SD Patil, F Papadimitrakopoulos… - Diabetes technology & …, 2004 - liebertpub.com
Background: Successful performance of implantable glucose biosensors for metabolic
monitoring is dependent on tissue compatibility. Negative immunostimulatory tissue …

Controlled release of dexamethasone from PLGA microspheres embedded within polyacid-containing PVA hydrogels

I Galeska, TK Kim, SD Patil, U Bhardwaj… - The AAPS journal, 2005 - Springer
The development of zero-order release systems capable of delivering drug (s) over
extended periods of time is deemed necessary for a variety of biomedical applications. We …

PLA/F68/Dexamethasone implants prepared by hot-melt extrusion for controlled release of anti-inflammatory drug to implantable medical devices: I. Preparation …

DX Li, G Guo, RR Fan, J Liang, X Deng, F Luo… - International journal of …, 2013 - Elsevier
Dexamethasone (Dex)-loaded implants were prepared by poly (d, l-lactic acid)(PLA) and
poly (ethylene glycol)-block-poly (propylene glycol)-block-poly (ethylene glycol) copolymer …

Fabrication of covered porous PLGA microspheres using hydrogen peroxide for controlled drug delivery and regenerative medicine

SE Bae, JS Son, K Park, DK Han - Journal of Controlled Release, 2009 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) microsphere has been a useful tool in delivering
therapeutic drugs and biologically active proteins. In this study, a covered porous PLGA …

[HTML][HTML] Chemical and spatial analysis of protein loaded PLGA microspheres for drug delivery applications

A Rafati, A Boussahel, KM Shakesheff… - Journal of controlled …, 2012 - Elsevier
Polymer microspheres for controlled release of therapeutic protein from within an
implantable scaffold were produced and analysed using complimentary techniques to probe …