The protein C (PC) anticoagulant system provides specific and efficient control of blood
coagulation. The system comprises circulating or membrane-bound protein components that …

The protein C anticoagulant pathway is recognized as a major control mechanism of blood
coagulation [reviewed in (1)]. Defects in protein C, protein S and thrombomodulin have all …

Control of the coagulation pathway requires mechanisms that serve to limit and localize the
clotting process. Protein C may serve as one of the major regulatory proteins. It differs from …

Unraveling the biochemical basis of the complex process of blood coagulation has been the
focus of intense investigation for more than 30 years. During this period of time …

Protein G is a plasma, vitamin K‐dependent zymogen of a serine protease that can inhibit
blood coagulation. Protein G is regulated by a series of reactions known as the protein G …

Although protein C was described as an anticoagulant in 1960 by Dr. Seegers and
colleagues, 1 widespread appreciation of the complexity of its activation, function, and …

The protein C system provides important control of blood coagulation by regulating the
activities of factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and …

In this study, we test the hypothesis that prothrombin levels may modulate activated protein
C (APC) anticoagulant activity. Prothrombin in purified systems or plasma dramatically …

The protein C anticoagulant pathway provides a mechanism for regulating the coagulation
process through the selective inactivation of factors Va and VIIIa. Recent studies have …

Protein C is a vitamin K-dependent plasma zymogen of a serine protease that plays a
central role in restraining the blood coagulation cascade-reviewed in (1-3). Thrombin that is …