A new paradigm in transplant immunology: At the crossroad of synthetic biology and biomaterials

Z Zhang, L Ding, X Zuo, H Feng, Q Xia - Med, 2023 - cell.com
Solid organ transplant (SOT) recipients require meticulously tailored immunosuppressive
regimens to minimize graft loss and mortality. Traditional approaches focus on inhibiting …

Transplantation immune responses: Biology, challenges, and opportunities using biomaterials

AZ Najm, AT Jalil, AMH Al Jawadri, HA Talib, ZK Hanan… - Gene Reports, 2023 - Elsevier
The organs or cells transplantation is well-established in clinics. However, despite the
increasing success rates and the broadening of various transplantation techniques, a key …

Unlocking Transplant Tolerance with Biomaterials

JPA Pham, MM Coronel - Advanced Healthcare Materials, 2024 - Wiley Online Library
For patients suffering from organ failure due to injury or autoimmune disease, allogeneic
organ transplantation with chronic immunosuppression is considered the gold standard in …

[HTML][HTML] Emerging strategies to bypass transplant rejection via biomaterial-assisted immunoengineering: Insights from islets and beyond

S Abbaszadeh, V Nosrati-Siahmazgi, K Musaie… - Advanced Drug Delivery …, 2023 - Elsevier
Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …

Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019 - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

Biomaterial-based approaches to engineering immune tolerance

AE Emerson, EM Slaby, SC Hiremath… - Biomaterials Science, 2020 - pubs.rsc.org
The development of biomaterial-based therapeutics to induce immune tolerance holds great
promise for the treatment of autoimmune diseases, allergy, and graft rejection in …

Recent advances in biomaterial-boosted adoptive cell therapy

Y Xue, J Che, X Ji, Y Li, J Xie, X Chen - Chemical Society Reviews, 2022 - pubs.rsc.org
Adoptive immunotherapies based on the transfer of functional immune cells hold great
promise in treating a wide range of malignant diseases, especially cancers, autoimmune …

Engineering strategies for allogeneic solid tissue acceptance

AR Sousa, JF Mano, MB Oliveira - Trends in Molecular Medicine, 2021 - cell.com
Advances in allogeneic transplantation of solid organs and tissues depend on our
understanding of mechanisms that mediate the prevention of graft rejection. For the past …

Engineering immune tolerance with biomaterials

JM Gammon, CM Jewell - Advanced healthcare materials, 2019 - Wiley Online Library
Autoimmune diseases, rejection of transplanted organs and grafts, chronic inflammatory
diseases, and immune‐mediated rejection of biologic drugs impact a large number of …

Tissue‐Targeted Drug Delivery Strategies to Promote Antigen‐Specific Immune Tolerance

Y Rui, HB Eppler, AA Yanes… - Advanced healthcare …, 2023 - Wiley Online Library
During autoimmunity or organ transplant rejection, the immune system attacks host or
transplanted tissue, causing debilitating inflammation for millions of patients. There is no …